association of -77t>c and arg194trp polymorphisms of xrcc1 with risk of coronary artery diseases in iranian population

Authors

saghar pahlavanneshan department of genetics, faculty of biological sciences, tarbiat modares university, tehran, iran

amirhossein ahmadi department of genetics, faculty of biological sciences, tarbiat modares university, tehran, iran

mohammadali boroumand tehran heart center, tehran university of medical sciences, tehran, iran

saeed sadeghian tehran heart center, tehran university of medical sciences, tehran, iran

abstract

objective(s): coronary artery disease (cad) is the leading cause of death in both male and female worldwide. the main cause of cad is the atherosclerosis of coronary arteries, which is, mostly caused by genetic alteration. 50% of such cases occur in mitotic cells where single-strand breaks occur spontaneously or due to ionizing radiation. x-ray repair cross-complementing protein 1 (xrcc1) as a key element, participate in the base excision repair (ber) and single-strand break repair (ssbr) pathways. it has been suggested that xrcc1 functions as a scaffold protein able to coordinate and facilitate the various steps of dna repair pathways. two single nucleotide polymorphisms (snps) (arg194trp and -77t>c) were reported to affect the function and expression of xrcc1, respectively. materials and methods:a case-control study was performed to investigate the relation between these polymorphisms and the cad development. a population of 406 individuals was screened for snps by restriction fragment length polymorphisms (rflp) method. results: xrcc1 arg194trp polymorphism was associated with increased risk of cad in examined population under a dominant model (odds-ratio=2.604, p-value=0.001). also the snp of -77t>c revealed a protective role in the population under a dominant model (odds-ratio=0.618, p-value=0.032). conclusion:our findings demonstrated a contributory role of these two snps in cad. furthermore, our results support the role of dna damages and the malfunctions of dna repair system in cardiovascular disease development in iranian patients.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Association of -77T>C and Arg194trp polymorphisms of XRCC1 with risk of coronary artery diseases in Iranian population

Objective(s): Coronary artery disease (CAD) is the leading cause of death in both male and female worldwide. The main cause of CAD is the atherosclerosis of coronary arteries, which is, mostly caused by genetic alteration. 50% of such cases occur in mitotic cells where single-strand breaks occur spontaneously or due to ionizing radiation. X-ray repair cross-complementing protein 1 (XRCC1) as a ...

full text

Association of -77T>C and Arg194trp polymorphisms of XRCC1 with risk of coronary artery diseases in Iranian population

OBJECTIVES Coronary artery disease (CAD) is the leading cause of death in both male and female worldwide. The main cause of CAD is the atherosclerosis of coronary arteries, which is, mostly caused by genetic alteration. 50% of such cases occur in mitotic cells where single-strand breaks occur spontaneously or due to ionizing radiation. X-ray repair cross-complementing protein 1 (XRCC1) as a key...

full text

the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region

چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...

15 صفحه اول

Association of two polymorphisms in MSH2 and XRCC1 genes with multiple sclerosis in Iranian population

Introduction: To protect genomes of all organisms from internal and external damages and maintain the genome integrity and the continuity of life, repair system has been developed in all living cells. Defects in repair system are responsible for various kinds of disease including cancers and neurodegenerative diseases such as Multiple sclerosis (MS). The relationship between various compone...

full text

Association of Htra1 Gene Polymorphisms with the Risk of Developing AMD in Iranian Population

Background: Half of the cases of vision loss in people under 60 years of age have been attributed to age-related macular degeneration (AMD). This is a multifactorial disease with late onset. It has been demonstrated that many different genetic loci are implicated in the risk of developing AMD in different populations. In the current study, we investigated the association of high-temperature &lr...

full text

XRCC1 Arg399Gln and Arg194Trp Polymorphisms and Risk of Systemic Lupus Erythematosus in an Iranian Population: A Pilot Study

BACKGROUND Evidences are suggesting that DNA damage is implicated in development of systemic lupus erythematosus (SLE). Therefore we focused on two common XRCC1 polymorphisms (Arg399Gln and Arg194Trp) in SLE susceptibility in South East of Iran. METHODS Peripheral blood DNA was extracted from 163 SLE patients and 180 healthy controls. PCR-restriction fragment length polymorphism method was us...

full text

My Resources

Save resource for easier access later


Journal title:
iranian journal of basic medical sciences

جلد ۱۹، شماره ۲، صفحات ۱۹۴-۲۰۰

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023